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For example, if you have sensitive skin, we might opt for a gentler peel or adjust the frequency of treatments to ensure your skin's integrity isn't compromised. This blood is then spun in a centrifuge, separating the platelets from other blood components. You'll notice your skin becoming firmer, smoother, and more youthful-looking. Learn more about Safe Botox injections New Westminster here Our team uses this information to craft a tailored plan that aligns with your vision and ensures the outcomes you're aiming for.
But the journey doesn't end there; the aftercare and results will redefine your skincare routine. Learn more about Manhas Health Co. here. We use cutting-edge techniques combined with high-quality, natural products to cleanse, exfoliate, and hydrate your skin, leaving it feeling refreshed and revitalized. To minimize complications, it's essential to choose a reputable provider experienced in these treatments.
Whether you're looking for skin revitalization, anti-aging solutions, or body contouring, they've got you covered with the latest technology and techniques. At Manhas Health Co, we customize each treatment plan to perfectly match your individual beauty goals and needs. So, as you embark on this journey with Forma Face Sculpting, you're not just enhancing your appearance; you're embracing a cutting-edge solution that promises to rejuvenate your skin from within.
Ready to take the first step towards your aesthetic goals? Evolve-X's cutting-edge technology targets specific areas for fat reduction, muscle definition, and skin tightening without requiring weeks or months to start seeing a difference. This modern approach at Manhas Health Co. Botox consultation services targets various concerns, from aesthetic changes to functional improvements, ensuring you feel your best.

She's your first point of contact and the one who'll guide you through your journey with us. From personalized skincare routines to advice on nutrition and exercise, we're committed to supporting you every step of the way. Afterward, there's no downtime required. Best Botox deals Understanding the differences between Morpheus 8 and PRP treatments sets the stage for appreciating real success stories from Safe Botox injections New Westminster. Lastly, they offer PRP (Platelet-Rich Plasma) treatments, utilizing your body's natural healing properties to rejuvenate and revitalize the vaginal area.

You'll feel minimal discomfort, thanks to a local anesthetic applied before the procedure. You're not just looking at a temporary fix but a long-term investment in your skin's health and appearance. Imagine reducing your headache days significantly, allowing you to enjoy life more fully. For optimal results, a series of treatments is recommended, tailored specifically to your skin's needs and your aesthetic goals.

If you experience any redness or swelling, a cool compress can provide relief. Once concentrated, this platelet-rich plasma is then injected back into your body in areas requiring healing or rejuvenation, such as the scalp for hair restoration. The magic lies in the application, executed by skilled professionals at Manhas Health Co, who ensure that your natural beauty is enhanced, not overshadowed. So, why wait?

At Manhas Health Co., we're not just about making you look good; we're about making you feel your best, using technology that sets new standards in aesthetic care. They're perfect for addressing issues like sun damage, acne scars, and uneven skin tone. Mark, skeptical at first, found solace in our hair restoration treatments.

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Top Botox brands This process not only tightens sagging skin but also improves its overall texture and tone.

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Entity Name Description Source
Botulinum toxin Description for Botulinum toxin Source
Skeletal muscle Description for Skeletal muscle Source
Eyelid Description for Eyelid Source
Eye drop Description for Eye drop Source
Injectable filler Description for Injectable filler Source
Marionette lines Description for Marionette lines Source
Lip Description for Lip Source
Dermatology Description for Dermatology Source
Mohs surgery Description for Mohs surgery Source
Skin cancer Description for Skin cancer Source
Varicose veins Description for Varicose veins Source
Melanocytic nevus Description for Melanocytic nevus Source
Collagen induction therapy Description for Collagen induction therapy Source
Platelet-rich plasma Description for Platelet-rich plasma Source
Pattern hair loss Description for Pattern hair loss Source
Skin care Description for Skin care Source
New Westminster Description for New Westminster Source
British Columbia Description for British Columbia Source
Rhinoplasty Description for Rhinoplasty Source
Masseter muscle Description for Masseter muscle Source
Submental triangle Description for Submental triangle Source
Hair loss Description for Hair loss Source
Scalp Description for Scalp Source
Hair follicle Description for Hair follicle Source
Hyperhidrosis Description for Hyperhidrosis Source
Restylane Description for Restylane Source
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The entrance to the Fraser is very striking—Extending miles to the right & left are low marsh lands (apparently of very rich qualities) & yet fr [sic] the Background of Superb Mountains—Swiss in outline, dark in woods, grandly towering into the clouds there is a sublimity that deeply impresses you. Everything is large and magnificent, worthy of the entrance to the Queen of England's dominions on the Pacific mainland. My imagination converted the silent marshes into Cuyp-like pictures of horses and cattle lazily fattening in rich meadows in a glowing sunset. The water of the deep clear Frazer was of a glassy stillness, not a ripple before us, except when a fish rose to the surface or broods of wild ducks fluttered away.

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Nearby Tourist Attractions

Mundy Park

Tourist attraction, City park
Mundy Park, 641 Hillcrest St, Coquitlam, BC V3J 6N9
178 acres of forest habitat with 2 lakes, sports facilities, disc golf & an outdoor pool.

Port Moody Station Museum

Tourist attraction, Entertainer, Historical landmark, History museum, Local history museum
Port Moody Station Museum, 2734 Murray St, Port Moody, BC V3H 1X2
Small destination offering local history exhibits & programs in a 1908 train station.

Rocky Point Park

Tourist attraction, City park
Rocky Point Park, 2800 Murray St, Port Moody, BC V3H 1X2
Waterfront recreation area with a pier, pool, skate park, restaurant, playground & boat ramp.

Shoreline Trail

Tourist attraction, City park, Hiking area
Shoreline Trail, 2934 Murray St, Port Moody, BC V3H 1X2
This walking trail along the Burrard Inlet offers sweeping views & allows leashed dogs.

Burnaby Fraser Foreshore Park

Tourist attraction, Park
Burnaby Fraser Foreshore Park, 7751 Fraser Park Dr, Burnaby, BC V5J 5L8
Riverfront park with outdoor gym equipment, dog area, picnic spots & a playground.

Hawthorne Rotary Park

Whalley
Tourist attraction, Park
Hawthorne Rotary Park, 10513 144 St, Surrey, BC V3T 4V4
Residential area park with a playground, spray pad, gardens, trails, picnic shelter & washrooms.

Glenlyon Foreshore Outlook

Tourist attraction, Historical landmark
Glenlyon Foreshore Outlook, 9186 Glenlyon Pkwy, Burnaby, BC V5J 5J8

World Police and Fire Games decoration

Metrotown
Tourist attraction
World Police and Fire Games decoration, 3789 BC-99A, Burnaby, BC V5H 1Y4

Citations and other links

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Whether you're looking to enhance your natural beauty with subtle Botox injections, add volume with fillers, or explore other rejuvenating treatments, we're here to make sure your results not only meet but exceed your expectations. You'll find a range of options, from non-invasive facials that rejuvenate the skin to more intensive procedures like microneedling and PRP (Platelet-Rich Plasma) therapy, which promote collagen production and cell turnover. If you tick these boxes, Advanced Forma Face Sculpting could be your gateway to rejuvenation. They understand that every skin type is different and requires a bespoke approach. Additionally, if you're dealing with urinary incontinence, a frequent concern post-childbirth or with aging, this treatment offers a promising solution.
That's the promise of your journey with Manhas Health Co. – where your beauty aspirations become our dedicated mission. Don't wait any longer to transform your body and boost your confidence. Ready to see the difference? This includes a detailed questionnaire about your medical history, lifestyle, and aesthetic goals. Anti-aging treatments
We understand that every individual's path to confidence is unique. Botox treatment plans But it's not all about the equipment. Well, dermaplaning is safe for most skin types, especially if you're seeking a non-invasive method to brighten your skin and achieve that coveted glow. The sagging that made you self-conscious? Non-invasive aesthetics Read more about Safe Botox injections New Westminster here
Merging science with nature, these products work in harmony with our professional treatments to amplify your results. You may not see immediate changes, but over the next few weeks, you'll notice hair growth slowing down, with each session at Manhas Health Co making a significant difference. If you prefer the digital route, their user-friendly website allows you to select the service you're interested in, choose your preferred date and time, and submit your booking in just a few clicks. At Manhas Health Co., we're committed to providing you with the most effective and comfortable experience.

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Seeing is believing, and in this case, the after results speak volumes about the power of Advanced Forma Face Sculpting to rejuvenate and refresh. Customized Botox treatments IPL, or Intense Pulsed Light therapy, works wonders on your skin by targeting and reducing the visibility of age spots, sun damage, and freckles. It's visibly reduced, leading to a more defined jawline and overall facial contour. By adhering to these recovery and care guidelines, you're setting yourself up for the best possible results from your vaginal rejuvenation treatment. Botox and PRP therapy It's also crucial to stop using any skincare products containing retinoids or other harsh chemicals a week prior, as these can make your skin more sensitive to the treatment.

Don't hesitate to ask about their credentials, experience, and the safety protocols they follow. Rest assured, from the moment you start with us, you're in capable hands committed to enhancing your natural beauty and boosting your confidence. It's important to keep the area clean and dry, and you may be prescribed special washes or creams to aid in your recovery. You'll find privacy and comfort are prioritized, creating a serene environment that feels like a retreat from the outside world.

Moreover, we provide you with educational resources and tips to maintain your results at home, emphasizing the importance of a holistic approach to care. From non-invasive treatments like facial rejuvenation and skincare therapies to more advanced procedures, our expert team is here to guide you every step of the way. Then there's James, whose thinning hairline had him wearing hats indoors. You'll lie back as the Evolve-X device is applied to your target areas, where it works to destroy fat cells, tighten skin, and build muscle.

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Each testimonial serves as a testament to the procedure's potential to positively alter lives, offering a compelling reason for considering this transformative journey. As you consider the possibilities of rejuvenating your skin or exploring innovative beauty treatments, remember that this clinic isn't just about surface-level beauty. Advanced Botox techniques Cosmetic injections You'll find an intuitive online booking system that lets you choose a time and date that best fits your schedule. You won't have to jump through hoops or wait forever on the phone. Over time, you'll notice your face achieving a more sculpted, toned appearance, as if you've turned back the clock.

It's a smart choice for those seeking effective, non-invasive body sculpting solutions. They understand that each individual's beauty journey is unique, and they're dedicated to providing customized treatment plans that reflect your personal goals and desires. Harnessing the power of state-of-the-art technology, we deliver highly personalized aesthetic treatments tailored to meet your unique needs. Secondly, our specialists aren't only experts in their field but also trained to prioritize patient care above all.

You might notice slight pain, redness, or swelling, which typically subsides within a day or two. It's designed to target those stubborn areas that don't seem to budge no matter how much you diet or exercise.

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When you think about the latest in aesthetic treatments, places like Beverly Hills or Seoul might spring to mind, but Manhas Health Co. is changing that narrative right in Safe Botox injections New Westminster. Neuromodulator injections You'll find that our team is incredibly approachable, ready to answer any questions and address concerns you might have.

Firstly, you'll notice a reduction in symptoms like dryness or discomfort, common issues that many face but seldom discuss openly. Our approach ensures that each procedure, from minimally invasive treatments to more extensive interventions, is chosen and adjusted specifically for you. It stimulates collagen production, essential for maintaining skin's elasticity and firmness. Beyond the immediate allure of these cosmetic enhancements lies a world of tailored treatment plans designed specifically for you, ensuring that your beauty goals are not just met but exceeded.

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The Forma technology utilizes radiofrequency energy to target deep layers of your skin, stimulating collagen production without damaging the surface. Our professionals are here to guide you through each step, from the initial consultation to the post-treatment care, ensuring you feel supported and informed.

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Battling acne scars for years left her hiding behind layers of makeup. While both Morpheus 8 and PRP treatments offer effective solutions for skin rejuvenation and hair restoration, their results can vary significantly depending on individual goals and conditions. At Manhas Health Co., you're in the hands of experts who genuinely care about helping you look and feel your best.

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Let's explore the science behind these treatments, their myriad benefits, and the real success stories that have made them a cornerstone of aesthetic rejuvenation in Safe Botox injections New Westminster. You'll find yourself moving with more confidence, liberated from the insecurities that once held you back. If you're noticing signs of aging, like fine lines or sagging skin, or if you're dealing with acne scars and uneven skin tone, this treatment could be exactly what you need.

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You'll notice the difference a customized approach makes. At Manhas Health, our experts bring a wealth of knowledge to your Evolve-X body sculpting journey, ensuring you're in the best hands for achieving your desired results. While we celebrate these incredible transformations, it's crucial to emphasize that your safety and comfort are always at the forefront of our services. Whether you're looking to reduce signs of aging, improve skin texture, or contour your body shape, our state-of-the-art technology makes it possible. Aesthetic clinic We believe in fostering long-term relationships with our clients, guiding you through your aesthetic journey with empathy and expertise.
You can rest easy knowing you're in safe hands, reducing the risks associated with more invasive procedures. This is because face sculpting promotes collagen production, the protein responsible for keeping your skin elastic and firm. As you consider embarking on this journey to rejuvenate your skin, understanding the process, preparing for your procedure, and following post-treatment care tips are crucial steps. Choosing Manhas Health Co means you're prioritizing your skin's health and beauty, with a team that's genuinely invested in seeing you achieve smooth, radiant skin.
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Military Policlinic in Legionowo, Poland

A clinic (or outpatient clinic or ambulatory care clinic) is a health facility that is primarily focused on the care of outpatients. Clinics can be privately operated or publicly managed and funded. They typically cover the primary care needs of populations in local communities, in contrast to larger hospitals which offer more specialized treatments and admit inpatients for overnight stays.

Most commonly, the English word clinic refers to a general practice, run by one or more general practitioners offering small therapeutic treatments, but it can also mean a specialist clinic. Some clinics retain the name "clinic" even while growing into institutions as large as major hospitals or becoming associated with a hospital or medical school.

Etymology

[edit]
The entrance to a surgery clinic in Greenwich, London

The word clinic derives from Ancient Greek κλίνειν klinein meaning to slope, lean or recline. Hence κλίνη klinē is a couch or bed and κλινικός klinikos is a physician who visits his patients in their beds.[1] In Latin, this became clīnicus.[2][3]

An early use of the word clinic was "one who receives baptism on a sick bed".[4]

Overview

[edit]
A medpunkt (health care access point) delivers primary health care to the residents of the village of Veliki Vrag, Russia.

Clinics are often associated with a general medical practice run by one or several general practitioners. Other types of clinics are run by the type of specialist associated with that type: physical therapy clinics by physiotherapists and psychology clinics by clinical psychologists, and so on for each health profession. (This can even hold true for certain services outside the medical field: for example, legal clinics are run by lawyers.)

Some clinics are operated in-house by employers, government organizations, or hospitals, and some clinical services are outsourced to private corporations which specialize in providing health services. In China, for example, owners of such clinics do not have formal medical education. There were 659,596 village clinics in China in 2011.[5]

Health care in India, China, Russia and Africa is provided to those regions' vast rural areas by mobile health clinics or roadside dispensaries, some of which integrate traditional medicine. In India these traditional clinics provide ayurvedic medicine and unani herbal medical practice. In each of these countries, traditional medicine tends to be a hereditary practice.

Function

[edit]
Policlinic in Karl-Marx-Stadt, German Democratic Republic

The function of clinics differs from country to country. For instance, a local general practice run by a single general practitioner provides primary health care and is usually run as a for-profit business by the owner, whereas a government-run specialist clinic may provide subsidized or specialized[dubiousdiscuss] health care.

Some clinics serve as a place for people with injuries or illnesses to be seen by a triage nurse or other health worker. In these clinics, the injury or illness may not be serious enough to require a visit to an emergency room (ER), but the person can be transferred to one if needed.

Treatment at these clinics is often less expensive than it would be at a casualty department. Also, unlike an ER these clinics are often not open on a 24/7/365 basis. They sometimes have access to diagnostic equipment such as X-ray machines, especially if the clinic is part of a larger facility. Doctors at such clinics can often refer patients to specialists if the need arises.[6]

Large outpatient clinics

[edit]
Children Policlinic in Novokosino District of Moscow

Large outpatient clinics vary in size, but can be as large as hospitals.

Function

[edit]

Typical large outpatient clinics house general medical practitioners (GPs) such as doctors and nurses to provide ambulatory care and some acute care services but lack the major surgical and pre- and post-operative care facilities commonly associated with hospitals.

Policlinic in Vilnius-Karoliniškės, Lithuania

Besides GPs, if a clinic is a polyclinic, it can house outpatient departments of some medical specialties, such as gynecology, dermatology, ophthalmology, otolaryngology, neurology, pulmonology, cardiology, and endocrinology. In some university cities, polyclinics contain outpatient departments for the entire teaching hospital in one building.

Internationally

[edit]
Policlinic in Písek, Czech Republic

Large outpatient clinics are a common type of healthcare facility in many countries, including France, Germany (long tradition), Switzerland, and most of the countries of Central and Eastern Europe (often using a mixed Soviet-German model), as well as in former Soviet republics such as Russia and Ukraine;[7] and in many countries across Asia and Africa.[8]

In Europe, especially in the Central and Eastern Europe, bigger outpatient health centers, commonly in cities and towns, are called policlinics (derived from the word polis, not from poly-).

Recent[when?] Russian governments have attempted to replace the policlinic model introduced during Soviet times with a more western model. However, this has failed.[9]

In the Czech Republic, many policlinics were privatized or leasehold and decentralized in the post-communist era: some of them are just lessors and coordinators of a healthcare provided by private doctor's offices in the policlinic building.[10]

India has also set up huge numbers of polyclinics for former defense personnel. The network envisages 426 polyclinics in 343 districts of the country which will benefit about 33 lakh (3.3 million) ex-servicemen residing in remote and far-flung areas.[11]

Policlinics are also the backbone of Cuba's primary care system and have been credited with a role in improving that nation's health indicators.[12]

Mobile clinics

[edit]
Hinduja National Hospital's mobile clinic
A mobile health clinic operated from a truck

Providing health services through mobile clinics provides accessible healthcare services to these remote areas that have yet to make their way in the politicized space. For example, mobile clinics have proved helpful in dealing with new settlement patterns in Costa Rica. Before foreign aid organizations or the state government became involved in healthcare, Costa Rica's people managed their own health maintenance and protection.[13] People relied on various socio-cultural adaptations and remedies to prevent illnesses, such as personal hygiene and settlement patterns.[13] When new settlements that sprang up along the coast became "artificial" communities, and due to lack of traditional home healing practices here, alternative methods such as mobile clinics had to be implemented in these communities for the protection and prevention of diseases.[13]

A study done in rural Namibia revealed the health changes of orphans, vulnerable children and non-vulnerable children (OVC) visiting a mobile clinic where health facilities are far from the remote villages.[14] Over 6 months, information on immunization status, diagnosis of anemia, skin and intestinal disorders, nutrition, dental disorders was collected and showed that visits to mobile clinics improved the overall health of children that visited regularly. It concluded that specified "planning of these programs in areas with similarly identified barriers may help correct the health disparities among Namibian OVC and could be a first step in improving child morbidity and mortality in difficult-to-reach rural areas."[14]

A mobile clinic run from a pickup truck in Yemen

Food supplementation in the context of routine mobile clinic visits also shows to have improved the nutritional status of children, and it needs further exploration as a way to reduce childhood malnutrition in resource-scarce areas. A cross-sectional study focussed on comparing acute and chronic undernutrition rates prior to and after a food-supplementation program as an adjunct to routine health care for children of migrant workers residing in rural communities in the Dominican Republic.[15] Rates of chronic undernutrition decreased from 33% to 18% after the initiation of the food-supplementation program and shows that the community members attending the mobile clinics are not just passively receiving the information but are incorporating it and helping keep their children nourished.[15]

Types

[edit]
Storefront clinic in Manhattan

There are many different types of clinics providing outpatient services. Such clinics may be public (government-funded) or private medical practices.

  • A CLSC are in Quebec; they are a type of free clinic funded by the provincial government; they provide service not covered by Canada's healthcare plan including social workers
  • In the United States, a free clinic provides free or low-cost healthcare for those with little or without insurance.
  • A retail-based clinic is housed in supermarkets and similar retail outlets providing walk-in health care, which may be staffed by nurse practitioners.
  • A general out-patient clinic offers general diagnoses or treatments without an overnight stay.
  • A polyclinic or policlinic provides a range of healthcare services (including diagnostics) without need of an overnight stay
  • A specialist clinic provides advanced diagnostic or treatment services for specific diseases or parts of the body. This type contrasts with general out-patient clinics.

See also

[edit]

References

[edit]
  1. ^ κλινικός in A Greek–English Lexicon. Retrieved 18 September 2016.
  2. ^ clinicus in A Latin Dictionary. Retrieved 18 September 2016.
  3. ^ Partridge, Eric. Origins: A short etymological dictionary of modern English. Book Club Associates, 1966.
  4. ^ Clinic, Webster's Revised Unabridged Dictionary, 1913.
  5. ^ "Statistical Communiqué on the 2011 National Economic and Social Development". stats.gov.cn. National Bureau of Statistics of China. 22 February 2012. Archived from the original on 6 April 2012. Retrieved 5 September 2012.
  6. ^ "Clinic search engine tools to find the right Clinic". 123 clinic. Retrieved 15 December 2016.
  7. ^ NLH – Health Management – Policlinics. Retrieved 3 July 2008.[permanent dead link]
  8. ^ Google
  9. ^ Ershova I, Rider O, Gorelov V (December 2007). "Policlinics in London". Lancet. 370 (9603): 1890–1. doi:10.1016/S0140-6736(07)61793-0. PMID 18068500. S2CID 43512994.
  10. ^ David Rath: Trnitá cesta privatizace českého zdravotnictví, Hospodářské noviny, 10 September 1996
  11. ^ "199 Additional Polyclinics For Ex-Servicemen". The Hindu. Chennai, India. 26 May 2010.
  12. ^ Cuba's primary health care revolution: 30 years on, Bulletin of the World Health Organization
  13. ^ a b c Morgan, Lynn M. (February 1993). Community Participation in Health: The Politics of Primary Care in Costa Rica. doi:10.1017/CBO9780511558092. ISBN 978-0-521-41898-0. Retrieved 8 May 2020. cite book: |website= ignored (help)
  14. ^ a b Aneni, Ehimen; De Beer, Ingrid H.; Hanson, Laura; Rijnen, Bas; Brenan, Alana T.; Feeley, Frank G. (2013). "Mobile primary healthcare services and health outcomes of children in rural Namibia". Rural and Remote Health. 13 (3): 2380. ISSN 1445-6354. PMID 24016257.
  15. ^ a b Parikh, Kavita; Marein-Efron, Gabriela; Huang, Shirley; O'Hare, Geraldine; Finalle, Rodney; Shah, Samir S. (September 2010). "Nutritional Status of Children after a Food-Supplementation Program Integrated with Routine Health Care through Mobile Clinics in Migrant Communities in the Dominican Republic". The American Journal of Tropical Medicine and Hygiene. 83 (3): 559–564. doi:10.4269/ajtmh.2010.09-0485. ISSN 0002-9637. PMC 2929051. PMID 20810820.

Wrinkles on the face and hands are a typical sign of aging

A wrinkle, also known as a rhytid, is a fold, ridge or crease in an otherwise smooth surface, such as on skin or fabric. Skin wrinkles typically appear as a result of ageing processes such as glycation,[1] habitual sleeping positions,[2] loss of body mass, sun damage,[3] or temporarily, as the result of prolonged immersion in water. Age wrinkling in the skin is promoted by habitual facial expressions, aging, sun damage, smoking, poor hydration, and various other factors.[4] In humans, it can also be prevented to some degree by avoiding excessive solar exposure and through diet (in particular through consumption of carotenoids, tocopherols and flavonoids, vitamins (A, C, D and E), essential omega-3-fatty acids, certain proteins and lactobacilli).[5]

Skin

[edit]

Causes for aging wrinkles

[edit]
A woman of European origin with facial wrinkles

Development of facial wrinkles is a kind of fibrosis of the skin. Misrepair-accumulation aging theory suggests that wrinkles develop from incorrect repairs of injured elastic fibers and collagen fibers.[6][7][8] Repeated extensions and compressions of the skin cause repeated injuries of extracellular fibers in derma. During the repairing process, some of the broken elastic fibers and collagen fibers are not regenerated and restored but replaced by altered fibers. When an elastic fiber is broken in an extended state, it may be replaced by a "long" collagen fiber. Accumulation of "long" collagen fibers makes part of the skin looser and stiffer, and as a consequence, a big fold of skin appears. When a "long" collagen is broken in a compressed state, it may be replaced by a "short" collagen fiber. The "shorter" collagen fibers will restrict the extension of "longer" fibers, and make the “long" fibers in a folding state permanently. A small fold, namely a permanent wrinkle, then appears.

Sleep wrinkles

[edit]

Sleep wrinkles are created and reinforced when the face is compressed against a pillow or bed surface in side or stomach sleeping positions during sleep.[9] They appear in predictable locations due to the underlying superficial musculoaponeurotic system (SMAS), and are usually distinct from wrinkles of facial expression.[10] As with wrinkles of facial expression, sleep wrinkles can deepen and become permanent over time, unless the habitual sleeping positions which cause the wrinkles are altered.[11]

Water-immersion wrinkling

[edit]
A wrinkled finger after a warm bath

The wrinkles that occur in skin over prolonged exposure to water are sometimes referred to as pruney fingers or water aging. This is a temporary skin condition where the skin on the palms of the hand or feet becomes wrinkly. This wrinkling response may have imparted an evolutionary benefit by providing improved traction in wet conditions,[12] and a better grasp of wet objects.[13] These results were called into question by a 2014 study that failed to reproduce any improvement of handling wet objects with wrinkled fingertips.[14] However, a 2020 study of gripping efficiency found that wrinkles decreased the force required to grip wet objects by 20%, supporting the traction hypothesis.[15]

Prior to a 1935 study, the common explanation was based on water absorption in the keratin-laden epithelial skin when immersed in water,[16] causing the skin to expand and resulting in a larger surface area, forcing it to wrinkle. Usually the tips of the fingers and toes are the first to wrinkle because of a thicker layer of keratin and an absence of hairs which secrete the protective oil called sebum.

Adult sole showing water immersion wrinkling

In the 1935 study, however, Lewis and Pickering were studying patients with palsy of the median nerve when they discovered that skin wrinkling did not occur in the areas of the patients' skin normally innervated by the damaged nerve. This suggested that the nervous system plays an essential role in wrinkling, so the phenomenon could not be entirely explained simply by water absorption. Recent research shows that wrinkling is related to vasoconstriction.[17][18] Water probably initiates the wrinkling process by altering the balance of electrolytes in the skin as it diffuses into the hands and soles via their many sweat ducts. This could alter the stability of the membranes of the many neurons that synapse on the many blood vessels underneath skin, causing them to fire more rapidly. Increased neuronal firing causes blood vessels to constrict, decreasing the amount of fluid underneath the skin. This decrease in fluid would cause a decrease in tension, causing the skin to become wrinkly.[19]

This insight resulted in bedside tests for nerve damage and vasoconstriction. Wrinkling is often scored with immersion of the hands for 30 minutes in water or EMLA cream with measurements steps of 5 minutes, and counting the number of visible wrinkles in time. Not all healthy persons have finger wrinkling after immersion, so it would be safe to say that sympathetic function is preserved if finger wrinkling after immersion in water is observed, but if the fingers emerge smooth it cannot be assumed that there is a lesion to the autonomic supply or to the peripheral nerves of the hand.[20]

Other animals with wrinkles

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Examples of wrinkles can be found in various animal species that grow loose, excess skin, particularly when they are young. Several breeds of dog, such as the Pug and the Shar Pei, have been bred to exaggerate this trait. In dogs bred for fighting, this is the result of selection for loose skin, which confers a protective advantage.[21]

Techniques for reducing the appearance of aging wrinkles

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A man receiving a botox injection

Current evidence suggests that tretinoin decreases cohesiveness of follicular epithelial cells, although the exact mode of action is unknown. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells.[22] Tretinoin is better known by the brand name Retin-A.

Topical glycosaminoglycans supplements can help to provide temporary restoration of enzyme balance to slow or prevent matrix breakdown and consequent onset of wrinkle formation. Glycosaminoglycans (GAGs) are produced by the body to maintain structural integrity in tissues and to maintain fluid balance. Hyaluronic acid is a type of GAG that promotes collagen synthesis, repair, and hydration. GAGs serve as a natural moisturizer and lubricant between epidermal cells to inhibit the production of matrix metalloproteinases (MMPs).

Dermal fillers are injectable products frequently used to correct wrinkles, and other depressions in the skin. They are often a kind of soft tissue designed to enable injection into the skin for purposes of improving the appearance. The most common products are based on hyaluronic acid and calcium hydroxylapatite.

Botulinum toxin is a neurotoxin protein produced by the bacterium Clostridium botulinum. Botox is a specific form of botulinum toxin manufactured by Allergan for both therapeutic and cosmetic use. Besides its cosmetic application, Botox is used in the treatment of other conditions including migraine headache and cervical dystonia (spasmodic torticollis) (a neuromuscular disorder involving the head and neck).[23]

Dysport, manufactured by Ipsen, received FDA approval and is now used to treat cervical dystonia as well as glabellar lines in adults. In 2010, another form of botulinum toxin, one free of complexing proteins, became available to Americans. Xeomin received FDA approval for medical indications in 2010 and cosmetic indications in 2011.

Botulinum toxin treats wrinkles by immobilizing the muscles which cause wrinkles. It is not appropriate for the treatment of all wrinkles; it is indicated for the treatment of glabellar lines (between the eyebrows) in adults. Any other usage is not approved by the FDA and is considered off-label use.

Laser resurfacing is FDA-cleared skin resurfacing procedure in which lasers are used to improve the condition of the skin.[citation needed] Two types of lasers are used to reduce the appearance of fine lines and wrinkles on the face; laser ablation, which removes thin layers of skin, and nonablative lasers that stimulate collagen production. Nonablative lasers are less effective than ablative ones but they are less invasive and recovery time is short. After the procedure people experience temporary redness, itching and swelling.

See also

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References

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  1. ^ Danby, FW (Jul–Aug 2010). "Nutrition and aging skin: sugar and glycation". Clin Dermatol. 4. 28 (4): 409–411. doi:10.1016/j.clindermatol.2010.03.018. PMID 20620757.
  2. ^ American Academy of Dermatology. "Causes of Aging". AgingSkinNet. American Academy of Dermatology. Retrieved 5 March 2013.
  3. ^ Cosmetic Procedures for Wrinkles
  4. ^ Anderson, Laurence. 2006. Looking Good, the Australian guide to skin care, cosmetic medicine and cosmetic surgery. AMPCo. Sydney. ISBN 0-85557-044-X.
  5. ^ Schagen, S. K.; Zampeli, V. A.; Makrantonaki, E.; Zouboulis, C. C. (2012). "Discovering the link between nutrition and skin aging". Dermato-Endocrinology. 4 (3): 298–307. doi:10.4161/derm.22876. PMC 3583891. PMID 23467449.
  6. ^ Wang, Jicun; Michelitsch, Thomas; Wunderlin, Arne; Mahadeva, Ravi (2009). "Aging as a consequence of Misrepair—a novel theory of aging". arXiv:0904.0575 [q-bio.TO].
  7. ^ Wang-Michelitsch, Jicun; Michelitsch, Thomas (2015). "Aging as a process of accumulation of Misrepairs". arXiv:1503.07163 [q-bio.TO].
  8. ^ Wang-Michelitsch, Jicun; Michelitsch, Thomas (2015). "Tissue fibrosis: a principal evidence for the central role of Misrepairs in aging". arXiv:1505.01376 [q-bio.TO].
  9. ^ Sarifakioglu, Nedim; Terzioglu, A.; Ates, L.; Aslan, G. (2004). "A New Phenomenon: 'Sleep Lines' on the Face". Scan J Plast Reconstr Surg Hand Surg. 38 (4): 244–247. doi:10.1080/02844310410027257. PMID 15370809. S2CID 25307487.
  10. ^ Fulton, James E.; Gaminchi, F. (1999). "Sleep Lines". Dermatol Surg. 25 (1): 59–62. doi:10.1046/j.1524-4725.1999.08073.x. PMID 9935097.
  11. ^ Sarifakioglu, Nedim; Terzioglu, A.; Ates, L.; Aslan, G. (2004). "A New Phenomenon: 'Sleep Lines' on the Face". Scan J Plast Reconstr Surg Hand Surg. 38 (4): 244–247 [246]. doi:10.1080/02844310410027257. PMID 15370809. S2CID 25307487.
  12. ^ Mark Changizi; Romann Weber; Ritesh Kotecha; Joseph Palazzo (2011). "Are Wet-Induced Wrinkled Fingers Primate Rain Treads?". Brain, Behavior and Evolution. 77 (4): 286–90. doi:10.1159/000328223. PMID 21701145.
  13. ^ Kareklas, Kyriacos; Nettle, Daniel; Smulders, Tom V (January 9, 2013). "Water-induced finger wrinkles improve handling of wet objects". Biol. Lett. 9 (2): 20120999. doi:10.1098/rsbl.2012.0999. PMC 3639753. PMID 23302867.
  14. ^ Haseleu, Julia; Omerbašić, Damir; Frenzel, Henning; Gross, Manfred; Lewin, Gary R. (2014). Goldreich, Daniel (ed.). "Water-Induced Finger Wrinkles Do Not Affect Touch Acuity or Dexterity in Handling Wet Objects". PLOS ONE. 9 (1): e84949. Bibcode:2014PLoSO...984949H. doi:10.1371/journal.pone.0084949. PMC 3885627. PMID 24416318.
  15. ^ Davis, N. (8 November 2020). "Water-immersion finger-wrinkling improves grip efficiency in handling wet objects". bioRxiv 10.1101/2020.11.07.372631.
  16. ^ "Dr Karl's Homework – Skin Wrinkles in Water (26/1/2000)". Abc.net.au. 2000-01-26. Retrieved 2019-04-30.
  17. ^ Einar P.V. Wilder-Smith; Adeline Chow (2003). "Water-immersion wrinkeling is due to vasoconstriction". Muscle & Nerve. 27 (3): 307–311. doi:10.1002/mus.10323. PMID 12635117. S2CID 45193684.
  18. ^ Einar P. V. Wilder-Smith (2004). "Water immersion wrinkling". Clinical Autonomic Research. 14 (2): 125–131. doi:10.1007/s10286-004-0172-4. PMID 15095056. S2CID 44938772.
  19. ^ H. Zhai, K.P. Whilem H. L. Maibach (2007). Dermatotoxicology. pp. 280–281.
  20. ^ G Alvarez, J Eurolo; P Canales (1980). "Finger wrinkling after immersion in water". British Medical Journal. 281 (6240): 586–587. doi:10.1136/bmj.281.6240.586-a. PMC 1713922. PMID 7427379.
  21. ^ The Dog Encyclopedia: The Definitive Visual Guide. Penguin. 15 August 2023. p. 84. ISBN 978-0-7440-8513-6.
  22. ^ Stefanaki C, Stratigos A, Katsambas A (June 2005). "Topical retinoids in the treatment of photoaging". J Cosmet Dermatol. 4 (2): 130–4. doi:10.1111/j.1473-2165.2005.40215.x. PMID 17166212. S2CID 44702740.
  23. ^ Brin MF, Lew MF, Adler CH, Comella CL, Factor SA, Jankovic J, O'Brien C, Murray JJ, Wallace JD, Willmer-Hulme A, Koller M (1999). "Safety and efficacy of NeuroBloc (botulinum toxin type B) in type A-resistant cervical dystonia". Neurology. 53 (7): 1431–8. doi:10.1212/WNL.53.7.1431. PMID 10534247.
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